The vehicle crashed into a guardrail north of the rest area on the southbound side just after 3:30 p.m.
Fire and rescue workers quickly removed the unresponsive victim, who had a possible broken arm and severe leg injury, responders said.
All southbound traffic from that area was temporarily stopped. An investigation was expected to keep the road closed for an extended period of time.
Paramedics from The Valley Hospital canceled AirMed One because of the severity of the victim's injuries.
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